Acanthosis nigricans (AN) is a common skin manifestation of systemic abnormality.
It presents with dark-brown hyperpigmentation and velvety thickening of the neck, under the arms, forehead, antecubital and popliteal fossae, groin and umbilicus.
AN can be caused by and associated with genetic predisposition, metabolic disorders (e.g. diabetes, PCOS, other endocrine diseases)/ obesity, autoimmune disease, cancer, medications.
Some associated factors include hair grooming, trauma, friction, heat, humidity, infections, and androgen hormones.
Treatment includes the management of underlying medical issues and/ or the use of .oral medications (e.g. metformin, thiazolidindiones), retinoids, lasers, chemical peels or dermabrasion
- Brady MF, Rawla P. Acanthosis Nigricans. StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2019 Nov 8
- Popa ML, Popa AC, Tanase C, Gheorghisan-Galateanu AA. Acanthosis Nigricans: To Be or Not to Be Afraid. Oncol Lett. 2019 May;17(5):4133-4138.