VITILIGO

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  • Vitiligo is a chronic autoimmune pigmentary condition

  • The highest incidence has been reported in India.  People of African descent do not seem to be preferentially affected, although, given the differences in pigment, it is more visible

  • It presents as symmetric bilateral well-demarcated light or white nonscaly patches anywhere on the body (non-segmental) or limited to one side of the body (segmental). Darker skin types may present with a pale skin color compared with healthy skin (vitiligo minor).  The disease can have a negative psychosocial impact

  • Vitiligo is as caused by an autoimmune attack of the pigment-producing (melanocytes) cells in the skin. New lesions may develop at the site of trauma of previously uninvolved skin (Koebner's phenomenon). 

  • It may be associated with other autoimmune conditions including thyroid disease and rheumatoid arthritis.    

  • Management includes topical and oral anti-inflammatory agents, narrow-band ultraviolet light therapy, and surgical grafting.

References: 

- Ezzedine K, Eleftheriadou V, Whitton M, van Geel N. Vitiligo. Lancet. 2015 Jul 4;386(9988):74-84.